Tuberous sclerosis complex is a relatively common genetic disease with an extremely wide range of manifestations, which can affect nearly any of the body’s organ systems. The ability to recognize and diagnosis this condition early is critical to providing adequate care to these patients. This requires knowledge of the full spectrum of findings and severities with which tuberous sclerosis can present. In addition, the time-dependent onset of many of the disease’s complications make preventative medicine a crucial component to patient care. Finally, knowledge of the genetic implications of the disease are essential to providing appropriate screening and care for patients’ parents, siblings, and potential children.

NUMBER OF CREDIT HOURS: The Harvard Medical School designates this educational activity for a maximum of 1 AMA PRA Category 1 credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

COST: $20.00
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OVERALL LEARNING OBJECTIVES:

1. More efficient recognition and diagnosis of infantile spasms and tuberous sclerosis complex at the level of the primary care physician.
2. Understanding of the genetic influence and considerations associated with tuberous sclerosis complex.
3. Recognition of the broad range of effects, complex constellation of surveillance procedures, and intricacy of therapies resulting from a diagnosis of tuberous sclerosis complex.

CLINICAL LEARNING OBJECTIVES:

1. More efficient recognition and diagnosis of infantile spasms and tuberous sclerosis complex at the level of the primary care physician.
2. Understanding of the genetic influence and considerations associated with tuberous sclerosis complex.
3. Recognition of the broad range of effects, complex constellation of surveillance procedures, and intricacy of therapies resulting from a diagnosis of tuberous sclerosis complex.

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RAJU KUCHERLAPATI, PHD Course Director

Raju Kucherlapati, Ph.D. is the Scientific Director of the Harvard Medical School-Partners HealthCare Center for Genetics and Genomics (HPCGG) and the Paul C. Cabot Professor of Genetics and Professor of Medicine at Harvard Medical School (HMS). He is the first Scientific Director of HPCGG. Dr. Kucherlapati was a member of the consortium to map and sequence the human and mouse genomes. His research interests are in the areas of discovery and characterization of human disease genes using a combination of human and mouse genetic and genomic approaches. He was a member of the National Advisory Council for Human Genome Research at the National Human Genomics Research Institute, co-chair of the steering committee for the National Cancer Institute’s Mouse Models for Human Cancer Consortium and served on the editorial board of the New England Journal of Medicine and was editor in chief of the journal Genomics. He is a fellow of the American Association for the Advancement of Science (AAAS). DISCLOSURE:

DAVID MUZYKEWICZ, Course Director

Bio and Photo Coming Soon. DISCLOSURE:

ELIZABETH THIELE, MD, PHD Course Director

Elizabeth A. Thiele is Director of the Pediatric Epilepsy Program and Director of the Carol and James Herscot Center for Tuberous Sclerosis Complex at Massachusetts General Hospital. Dr. Thiele is also Associate Professor of Neurology at Harvard Medical School. Dr. Thiele is board certified in neurology, with special qualifications in child neurology and clinical neurophysiology. She has received awards for teaching in residency programs at Massachusetts General Hospital and the Longwood Neurology Program, for research mentoring from the Harvard MIT Health Sciences and Technology program, and was nominated for a Humanism in Medicine Award from Harvard Medical School. Dr. Thiele received her A.B., scl from Washington University, St. Louis in 1983 and her M.D. and Ph.D. from The Johns Hopkins University School of Medicine in 1990. DISCLOSURE: Company: Athena Diagnostics, Type of Relationship: Consultant, Content: TSC Company: Ovation Pharmaceuticals, Type of Relationship: Consultant, Content: Vigabstin

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SANJIV CHOPRA, MD Reviewer

Dr. Sanjiv Chopra is Professor of Medicine and Faculty Dean for Continuing Medical Education at Harvard Medical School. He is Director, Clinical Hepatology at the Beth Israel Deaconess Medical Center, Boston, Massachusetts. Dr. Chopra has approximately 100 publications. He has four books to his credit: Disorders of the Liver, which has been translated into Japanese and Italian, Pathophysiology of Gastrointestinal Diseases, Gastroenterology: Problems in Primary Care, and Dr. Sanjiv Chopra's Liver Book. Dr. Chopra is an Editor-in-Chief of UpToDate in Gastroenterology and Hepatology, an outstanding and innovative clinical reference on CD-ROM. Dr. Chopra was the recipient of the George W. Thorn Award, presented by the Brigham and Women's Hospital Housestaff, Harvard Medical School, in 1985 for his outstanding contribution to clinical education. In 1991 he received the highest accolade from the 1991 graduating class of Harvard Medical School, The Excellence in Teaching Award. The citation read: "Outstanding clinician, devoted teacher and mentor. We thank you for your dedication to excellence in teaching. -Harvard Medical School. Class of 1991." In 1995 Dr. Chopra was the recipient of the Robert S. Stone Award, a prestigious award given to a faculty member who is an outstanding clinician and teacher and is chosen by colleagues, housestaff and students from the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. In 1999 Boston Magazine listed Dr. Chopra as one of the finest doctors in his specialty. In 2003 he was honored by being the recipient of the AGA Distinguished Educator Award. Dr. Chopra is widely acclaimed as a superb educator. He is a most sought after speaker and has addressed medical audiences throughout the United States and in several countries abroad. DISCLOSURE: Scherring-Plough: Speakers' bureau Roche: Speakers' bureau UpToDate: Royalty income

JONATHAN A. EDLOW, MD Reviewer

Dr. Edlow was graduated from the University of Maryland School of Medicine in 1978. He trained in Internal Medicine at the Boston City Hospital and since finishing in 1981, he has practiced full-time emergency medicine. He is board-certified in both specialties. Since 1999, he has served as Vice-chairman of the Department of Emergency Medicine at Beth Israel Deaconess Medical Center and is also an Associate Professor of Medicine at Harvard Medical School. Dr. Edlow’s clinical interests include tick-borne diseases and neurological emergencies. He lectures and publishes regularly on such topics as stroke, TIA, subarachnoid hemorrhage, various causes of weakness and dizziness. As well, he has written an award-winning book on the history of Lyme disease – Bull’s Eye: unraveling the medical mystery of Lyme disease. DISCLOSURE: Novo Nordisk: Paid speaker

MUSTAFA SAHIN, Reviewer

Bio and Photo Coming Soon. DISCLOSURE:

JOAN STOLER, MD Reviewer

Dr. Stoler is a clinical geneticist at the Children’s Hospital Boston and an assistant professor of pediatrics at Harvard Medical School. She is the director of clinical research for the division of Genetics in the Department of Medicine. She is the course director for the Harvard Medical School elective in genetics at Children’s Hospital and the site director for the fellowship in clinical genetics. She is also on the faculty in the Department of Biology at Brandeis University, teaching two courses on Clinical Genetics in the Genetic Counseling Program. She received her M.D. degree from the Columbia University College of Physicians and Surgeons and did her residency in pediatrics at Tufts Medical Center. She completed a fellowship in Adolescent Medicine at the Children’s Hospital, Boston and later went on to complete a fellowship in Clinical Genetics at Harvard Medical School and Massachusetts General Hospital. DISCLOSURE: Faculty Disclosure: none

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NUMBER OF CREDITS: 1 

Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The Harvard Medical School designates this educational activity for a maximum of 1 AMA PRA Category 1 credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Upon completion of the course you will get a certificate via e-mail within 2 weeks.

Click the image to view a sample of the certificate

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