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Genetics: Colon Cancer

Course Description | Faculty | Accreditation | General Information

Course Description

Acknowledgement: This online activity is supported by educational grants from Celera and the Applera Charitable Foundation.

The Colon Cancer Genetics course is designed to enhance the participants’ knowledge of inherited colon cancer syndromes, particularly Hereditary Nonpolyposis Colorectal Cancer (HNPCC, or Lynch Syndrome). The participant will be guided through how to identifying patients at a high-risk of harboring genetic mutations that predispose them to colon cancer. Participants will also learn the genetic testing modalities that can be offered to these patients. Additionally, the screening recommendations for these patients and their family members will be reviewed.

Original Release: 6/17/2009
Most Recent Update: 7/6/2010
Termination Date: 7/6/2013

NUMBER OF CREDIT HOURS: The Harvard Medical School designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This course should take approximately 1 hours to complete.

COST: $20.00 for the average learner. Participants living in emerging nations receive a 50% discount or can register for free. See our International Pricing Page for details.

OVERALL LEARNING OBJECTIVES:

  1. Improve knowledge of inherited colon cancer syndromes, specifically Hereditary Nonpolyposis Colorectal Cancer (HNPCC, or Lynch Syndrome)

CLINICAL LEARNING OBJECTIVES:

  1. Identify the subset of colon cancer patient with an inherited susceptibility.
  2. Learn the testing algorithm for individuals whom you may suspect have Hereditary Nonpolyposis Colorectal Cancer (HNPCC, or Lynch Syndrome).
  3. Understand the screening recommendations for affected individuals and their family members.
  4. Learn the prediction models available to assess a patient’s risk of having Hereditary Nonpolyposis Colorectal Cancer (HNPCC, or Lynch Syndrome)

METHOD OF PARTICIPATION:

Registrants participate in the learning process by answering interactive multiple choice questions that are dispersed throughout the case presentation. You must answer a question correctly in order to continue through the course. If you answer a question incorrectly, you will be prompted to try again.

In order to earn credit, physicians must complete the entire educational activity before the termination date (see above). Non-physicians may register for the course but are not eligible for AMA PRA Category 1 Credits™. Instead, non-physicians will earn a certificate of participation after successfully completing the course before its termination date.

COMBINATION OF MEDIA USED:

This internet enduring material is a case-based, interactive presentation comprised mainly of text, interactive questions, and images. A variety of media, including video clips, audio clips, and Flash animation, may be presented. Links to any necessary plugins are provided when necessary, but no plugins are required for general use of the CME website, and you may skip the multimedia presentation(s) within the course if you choose.

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Faculty
RAJU KUCHERLAPATI, PhD
Course Director
Raju Kucherlapati, Ph.D. is the Scientific Director of the Harvard Medical School-Partners HealthCare Center for Genetics and Genomics (HPCGG) and the Paul C. Cabot Professor of Genetics and Professor of Medicine at Harvard Medical School (HMS). He is the first Scientific Director of HPCGG.

Dr. Kucherlapati was a member of the consortium to map and sequence the human and mouse genomes. His research interests are in the areas of discovery and characterization of human disease genes using a combination of human and mouse genetic and genomic approaches. He was a member of the National Advisory Council for Human Genome Research at the National Human Genomics Research Institute, co-chair of the steering committee for the National Cancer Institute’s Mouse Models for Human Cancer Consortium and served on the editorial board of the New England Journal of Medicine and was editor in chief of the journal Genomics. He is a fellow of the American Association for the Advancement of Science (AAAS).

DISCLOSURE:
Reported no relevant financial relationships with commercial entities



JENNIFER SPARR, MD
Course Director
Jennifer Sparr graduated with a Bachelor of Arts in Chemistry from the University of Pennsylvania in 2004. She is currently a medical student at the Albert Einstein College of Medicine. From 2007-2008 she worked as a Clinical Research Coordinator for the Pancreatic Cancer Genes Study (PAGES) at the Dana-Farber Cancer Institute. During this time she worked closely with physicians and genetic counselors in the Gastrointestinal Risk and Prevention Clinic to enroll patients in research studies. She will graduate from the Albert Einstein College of Medicine in 2009 and will begin her Internal Medicine residency at Johns Hopkins Hospital in July, 2009.

DISCLOSURE:
Reported no relevant financial relationships with commercial entities



SAPNA SYNGAL, MD, MPH
Course Director
Dr. Sapna Syngal received her MD from McGill University in 1990 and completed her clinical training in internal medicine and gastroenterology at Brigham and Women's Hospital. She received her Masters in Public Health from Harvard School of Public Health and completed a research fellowship at the Harvard Education Program in Cancer Prevention. In 1995, she joined the faculty of Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School where she is principally involved in clinical care and research in the genetics, early detection and prevention of gastrointestinal cancer. She is the Director of Gastroenterology at the Dana-Farber/Brigham and Women’s Cancer Center, the Director of the GI Cancer Risk and Prevention Program at Dana-Farber Cancer Institute, and Associate Professor of Medicine at Harvard Medical School. She directs a NIH-funded research program that focuses on the genetics and prevention of colorectal and pancreatic cancers. Dr. Syngal has been recognized nationwide for her expertise in genetics and gastrointestinal malignancies. She was elected to the American Society of Clinical Investigation in 2009.

DISCLOSURE:
Reported no relevant financial relationships with commercial entities



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Reviewers
RICHARD CHUNG, MD
Reviewer
Dr. Chung is the Director of Adolescent Medicine at Duke University Medical Center in Durham, NC, and is an assistant professor of pediatrics and internal medicine. Dr. Chung earned his medical degree at Yale University School of Medicine and trained in pediatrics and internal medicine at Duke prior to training in Adolescent and Young Adult Medicine at Children’s Hospital Boston. Dr. Chung’s clinical and research interests center on preventive and chronic disease care of adolescents and young adults. Dr. Chung is a Fellow of the American Academy of Pediatrics and a member of the Society for Adolescent Health and Medicine.

DISCLOSURE:
Myriad, Consultant, genetic testing



ROBERT MAYER, MD
Reviewer
Dr. Mayer is Vice Chair for Academic Affairs of the Department of Medical Oncology at the Dana-Farber Cancer Institute, Senior Physician at the Brigham and Women's Hospital, Physician at the Massachusetts General Hospital, and the Stephen B. Kay Professor of Medicine at the Harvard Medical School where he is also Faculty Associate Dean for Admissions. He has directed the Institute's Medical Oncology Training Program since 1975 and is presently the Director of the Hematology/Oncology Fellowship Program of Dana-Farber/Partners CancerCare. Dr. Mayer's research interests focus on gastrointestinal cancer a subject about which he has published extensively. Dr. Mayer established the Center for Gastrointestinal Oncology at the Dana-Farber Cancer Institute and is the past Chair of the Gastrointestinal Cancer Committee of the Cancer and Leukemia Group B, a cooperative group sponsored by the National Cancer Institute. He has served as an Associate Editor for the New England Journal of Medicine, is a past President of the American Society of Clinical Oncology and the Association of Subspecialty Professors and is a former member of the Executive Committee of the American Board of Internal Medicine. Dr. Mayer is a graduate of Williams College and the Harvard Medical School.

DISCLOSURE:
Reported no relevant financial relationships with commercial entities



MALCOLM K. ROBINSON
Reviewer
Dr. Robinson is an Assistant Professor of Surgery at Brigham and Women's Hospital in Boston, MA.

DISCLOSURE:
Reported no relevant financial relationships with commercial entities



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Course Planners
SANJIV CHOPRA, MD
Planner
Dr. Sanjiv Chopra is Professor of Medicine at Harvard Medical School. He is also the the James Tullis Firm Chief in the Department of Medicine and a Senior Consultant in Hepatology at the Beth Israel Deaconess Medical Center, Boston. He served as Faculty Dean for Continuing Education at HMS for 12 years. Dr. Chopra has more than 150 publications and seven books to his credit. Dr. Chopra is Editor-in-Chief of the Hepatology Section of UpToDate, the most widely used electronic textbook in the world subscribed to by more than 850,000 physicians in 149 countries. He is also the recipient of numerous awards and accolades. For a complete bio, click here.

DISCLOSURE:
Reported no relevant financial relationships with commercial entities



ERIN HARVEY, MSC, CGC
Planner
Erin K. Harvey, MSc, CGC, was the Assistant Director of Education for Partners Healthcare Center for Personalized Genetic Medicine (PCPGM) from 2008 to 2011. She is a board-certified genetic counselor and has worked with a wide range of primary healthcare professionals in the development of genetics-related, case-based continuing medical education (CME). In addition to being the series editor for PCPGM’s genetics CMEs, she coordinated an advanced human genetics course for Harvard Medical School’s Clinical Genetics Residency training program. In 2011, she accepted a position with Genzyme as a Scientific Communications Principal for the Personalized Genetic Health division. Prior to joining PCPGM, Ms. Harvey spent five years with the National Coalition for Health Professional Education in Genetics, and was seconded for one year to the United Kingdom to help a similar organization there – the National Genetics Education and Development Centre – create genetics resources for the UK’s nationalized medical education curriculum. Ms. Harvey received her master’s degree in science in 2003 from the Johns Hopkins University/National Institutes of Health joint genetic counseling training program. She received a B.A. in English Writing from St. Edward’s University in Austin, Texas in 1993, and worked as a journalist prior to pursuing a career in the biological sciences.

DISCLOSURE:
Reported no relevant financial relationships with commercial entities



ANDI LONG, EdM
Planner
Andi Long directs the Department of Continuing Education’s Distance Learning group, which offers a variety of online continuing medical education programs to health care professionals around the world. Andi develops strategies for new pilot programs and systematically rolls out new distance learning initiatives and has a leadership role in IT planning and other online processes for HMS DCE. She oversees the day-to-day operations of each distance learning activity and ensures ACCME compliance across all enduring programs. She has had the privilege of working with hundreds of Harvard Medical School Faculty members to develop high-quality, engaging online programs that physicians in more than 170 countries have taken part in. Andi earned her Ed.M. in Technology, Innovation, and Education from Harvard Graduate School of Education and graduated from Bridgewater State College with a degree in English. Her professional interests focus on teaching and learning with new technologies and online course development.

DISCLOSURE:
Reported no relevant financial relationships with commercial entities



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Accreditation

NUMBER OF CREDITS: 1 

The Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Harvard Medical School designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This course should take approximately 1 hours to complete.

Within 2 weeks of completing the course, you will receive your certificate via email.

Click the image to view a sample of the certificate


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General Information

HARDWARE/SOFTWARE REQUIREMENTS

Computers
Any computer running Windows, Mac OS, or Unix machines are supported.


Internet Connection
Your computer should be configured to access the Internet. A high speed internet connection may be required to view some of the large multimedia files.

Browsers
Firefox or Internet Explorer 5.5 or higher are recommended. JavaScript and cookies must be enabled.

Plugins
Some of the multimedia resources in this course require Apple Quicktime, RealMedia, or a Flash player. You will be prompted to download the appropriate plugin when necessary. No plugins are required for general use of the CME website, and you may skip the multimedia presentation(s) within the course if you choose.


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