Acknowledgement: This course is supported by educational grants from Celera and the Applera Charitable Foundation.

This case study illustrates a common clinical scenario (i.e., renal cystic disease in a proband with an inconclusive family history) and many issues related to diagnosis and management of polycystic kidney disease.

NUMBER OF CREDIT HOURS: The Harvard Medical School designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This course should take approximately 1 hours to complete.

COST: $20.00 for the average learner. Participants living in emerging nations receive a 50% discount or can register for free. See our International Pricing Page for details.

OVERALL LEARNING OBJECTIVES:
After completing this course, the participant will be able to:

1. Describe the clinical findings associated with autosomal dominant polycystic kidney disease (ADPKD),
2. Understand the genetic basis of ADPKD and related disorders, and
3. Appreciate the issues related to genetic testing in ADPKD.

METHOD OF PARTICIPATION:

Registrants participate in the learning process by answering interactive multiple choice questions that are dispersed throughout the case presentation. You must answer a question correctly in order to continue through the course. If you answer a question incorrectly, you will be prompted to try again.

In order to earn credit, physicians must complete the entire educational activity before the termination date (see above). Non-physicians may register for the course but are not eligible for AMA PRA Category 1 Credits™. Instead, non-physicians will earn a certificate of participation after successfully completing the course before its termination date.

COMBINATION OF MEDIA USED:

This internet enduring material is a case-based, interactive presentation comprised mainly of text, interactive questions, and images. A variety of media, including video clips, audio clips, and Flash animation, may be presented. Links to any necessary plugins are provided when necessary, but no plugins are required for general use of the CME website, and you may skip the multimedia presentation(s) within the course if you choose.

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RAJU KUCHERLAPATI, PhD Course Co-Director

Raju Kucherlapati, Ph.D. is the Scientific Director of the Harvard Medical School-Partners HealthCare Center for Genetics and Genomics (HPCGG) and the Paul C. Cabot Professor of Genetics and Professor of Medicine at Harvard Medical School (HMS). He is the first Scientific Director of HPCGG. Dr. Kucherlapati was a member of the consortium to map and sequence the human and mouse genomes. His research interests are in the areas of discovery and characterization of human disease genes using a combination of human and mouse genetic and genomic approaches. He was a member of the National Advisory Council for Human Genome Research at the National Human Genomics Research Institute, co-chair of the steering committee for the National Cancer Institute’s Mouse Models for Human Cancer Consortium and served on the editorial board of the New England Journal of Medicine and was editor in chief of the journal Genomics. He is a fellow of the American Association for the Advancement of Science (AAAS). DISCLOSURE: Reported no relevant financial relationships with commercial entities

MARTIN POLLAK, MD Course Co-Director

Martin Pollak is a Professor of Medicine at Harvard Medical School and Chief for the Division of Nephrology at Beth Israel Deaconess Medical Center. Dr. Pollak received his MD degree from New York University, completed a residency in Internal Medicine at Columbia-Presbyterian Medical Center in New York, clinical nephrology fellowship at the Brigham and Women's Hospital, and followed by a post-doctoral fellowship in the Department of Genetics at Harvard Medical School. Dr. Pollak conducts research into the molecular genetic basis of kidney disease. His laboratory uses a variety of experimental tools to understand the genetic causes of human kidney disease. His laboratory has made major contributions to understanding the molecular and genetic basis of diseases of human glomerular function and in understanding the high rate of kidney disease in individuals of recent African descent. DISCLOSURE: Reported no relevant financial relationships with commercial entities.

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YORK PEI, Reviewer

Bio and Photo Coming Soon. DISCLOSURE: Reported no relevant financial relationships with commercial entities

THEODORE I. STEINMAN, MD Reviewer

Dr. Steinman, a Philadelphia native, received his undergraduate degree from Penn State University (B.S. in Pre-Medicine) and his M.D. degree from Georgetown University School of Medicine in 1964. Internship and junior residency in Internal Medicine were at Cedars-Sinai Medical Center, Los Angeles, CA. Senior medical residency was completed at Beth Israel Hospital, Boston in 1969, following a 2 year tour of duty in the U.S. Navy (1966-1968), serving one year in Vietnam with the Marines. Nephrology Fellowship training was at Tufts New England Medical Center (1969-1971) under the leadership of Drs. William B. Schwartz and Jerome B. Kassirer. From there Dr. Steinman returned to Beth Israel Hospital to start the dialysis and kidney transplantation program, and lead the program for 31 years. Dr. Steinman is a Clinical \ Professor of Medicine, Harvard Medical School and Senior Physician at both Beth Israel Deaconess Medical Center and Brigham and Woman’s Hospital, Boston. Regional and national leadership positions are indicated by his having been President, Renal Physicians Association; Chairman, Scientific Advisory Committee, Polycystic Kidney Foundation; President, National Kidney Foundation Region I; both President and Chairman, National Kidney Foundation of Massachusetts, Rhode Island, New Hampshire, Vermont. He served on the Executive Committee for the Council of American Kidney Societies. He was a member of the Medical Advisory Board, Kidney Disease Outcome Quality Initiative (K/DOQI), which established guidelines of care for patients with kidney disease. He served on the Steering Committee (NIDDK) for the National Kidney Disease Education Program. Currently he sits on the Board of Directors, Polycystic Kidney Disease Foundation and remains an active member of the Medical Advisory Board, NKF of MA, RI, NH, VT. DISCLOSURE: Company: Advance Medical Type of Relationship: Consultant Content Area: 2nd Medical Opinion

TERRY WATNICK, Reviewer

Bio and Photo Coming Soon. DISCLOSURE: Reported no relevant relationships with commercial entities.

RANDY WERTHEIMER, Reviewer

Bio and Photo Coming Soon. DISCLOSURE: Reported no relevant financial relationships with commercial entities

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SANJIV CHOPRA, MD Planner

Dr. Sanjiv Chopra is Professor of Medicine and Faculty Dean for Continuing Medical Education at Harvard Medical School and Senior Consultant in Hepatology at the Beth Israel Deaconess Medical Center, Boston. In his role as Faculty Dean for Continuing Education, Dr. Chopra provides oversight and leadership of the Department and oversees the academic development of our programs. Dr. Chopra is an experienced clinician, researcher, and educator. In his research roles, he has served both as a principal investigator as well as co-investigator. He has more than 120 publications and five books to his credit, addressing topics in disease states, patient care, and leadership. Dr. Chopra’s teaching experience is extensive, and he has won numerous teaching awards for his work with medical students, residents and physicians. Currently, he directs and speaks at 10 multiday CME courses, nine of which are through HMS. For his full bio, please click here. DISCLOSURE: Reported no relevant financial relationships with commercial entities

ERIN HARVEY, MSC, CGC Planner

Erin K. Harvey, MSc, CGC, was the Assistant Director of Education for Partners Healthcare Center for Personalized Genetic Medicine (PCPGM) from 2008 to 2011. She is a board-certified genetic counselor and has worked with a wide range of primary healthcare professionals in the development of genetics-related, case-based continuing medical education (CME). In addition to being the series editor for PCPGM’s genetics CMEs, she coordinated an advanced human genetics course for Harvard Medical School’s Clinical Genetics Residency training program. In 2011, she accepted a position with Genzyme as a Scientific Communications Principal for the Personalized Genetic Health division. Prior to joining PCPGM, Ms. Harvey spent five years with the National Coalition for Health Professional Education in Genetics, and was seconded for one year to the United Kingdom to help a similar organization there – the National Genetics Education and Development Centre – create genetics resources for the UK’s nationalized medical education curriculum. Ms. Harvey received her master’s degree in science in 2003 from the Johns Hopkins University/National Institutes of Health joint genetic counseling training program. She received a B.A. in English Writing from St. Edward’s University in Austin, Texas in 1993, and worked as a journalist prior to pursuing a career in the biological sciences. DISCLOSURE: Reported no relevant financial relationships with commercial entities

ANDI LONG, EDM Planner

Andi Long directs the Department of Continuing Education’s Distance Learning group, which offers a variety of online continuing medical education programs to health care professionals around the world. Andi develops strategies for new pilot programs and systematically rolls out new distance learning initiatives and has a leadership role in IT planning and other online processes for HMS DCE. She oversees the day-to-day operations of each distance learning activity and ensures ACCME compliance across all enduring programs. She has had the privilege of working with hundreds of Harvard Medical School Faculty members to develop high-quality, engaging online programs that physicians in more than 170 countries have taken part in. Andi earned her Ed.M. in Technology, Innovation, and Education from Harvard Graduate School of Education and graduated from Bridgewater State College, summa cum laude, with a degree in English. Her professional interests focus on teaching and learning with new technologies and online course development. DISCLOSURE: Reported no relevant financial relationships with commercial entities

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NUMBER OF CREDITS: 1 

The Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Harvard Medical School designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This course should take approximately 1 hours to complete.

Within 2 weeks of completing the course, you will receive your certificate via email.

Click the image to view a sample of the certificate

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